Advances in ophthalmic drug delivery.

Recent Advances in Ophthalmic Drug Delivery System

In the present update on ocular drug delivery system, particulate carrier, the tremendous advances in ocular drug delivery system, the polymers used in particulate carriers for ocular dosage forms, the use of drug complexes and other technological advances are discussed. This review focuses on recent literature regarding mucoadhesive particulate dosage forms with special attention to in vivo st...

Design of eudragit RL nanoparticles by nanoemulsion method as carriers for ophthalmic drug delivery of ketotifen fumarate

Objective(s): Ketotifen fumarate (KF) is a selective and noncompetitive histamine antagonist (H1-receptor) that is used topically in the treatment of allergic conditions of rhinitis and conjunctivitis. The aim of this study was to formulate and improve an ophthalmic delivery system of KF.Ocular nanoparticles were prepared with the objective of reducing the frequency of administration and obtain...

Advances in Targeted Drug Delivery

Advances in Targeted Drug Delivery

Ocular Iontophoresis for Anterior and Posterior Segment Drug Delivery

Over the recent decades, there has been seismic shift in the field of ocular drug delivery ranging from dosage form design to drug product commercialization. Advancements in the fields of nanotechnology, biomedical engineering and clinical science significantly improved the feasibility of ocular drug delivery. Despite these technological advances, there exists need to deliver drugs in therapeut...

Improvements in Topical Ocular Drug Delivery Systems: Hydrogels and Contact Lenses.

PURPOSE Conventional ophthalmic systems present very low corneal systemic bioavailability due to the nasolacrimal drainage and the difficulty to deliver the drug in the posterior segment of ocular tissue. For these reasons, recent advances have focused on the development of new ophthalmic drug delivery systems. This review provides an insight into the various constraints associated with ocular ...